Brand  (β version)

PDB ID: 6RAV

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
JGQ 4-[(2~{S},4~{S})-4-ethoxy-1-[(5-methoxy-7-methyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 6RAV   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Complement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid
Release Data : 2019-04-17
Compound :
mol_id molecule chains synonym
1 Complement factor B AAA,BBB C3/C5 convertase,Glycine-rich beta glycoprotein,GBG,PBF2,Properdin factor B
ec: 3.4.21.47
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Drosophila melanogaster  (taxid:7227)
gene: CFB, BF, BFD
Authors : Adams, C.M., Sellner, H., Ehara, T., Mac Sweeney, A., Crowley, M., Anderson, K., Karki, R., Mainolfi, N., Valeur, E., Sirockin, F., Gerhartz, B., Erbel, P., Hughes, N., Smith, T.M., Cumin, F., Argikar, U., Mogi, M., Sedrani, R., Wiesmann, C., Jaffee, B., Maibaum, J., Flohr, S., Harrison, R., Eder, J.
Keywords : Complement, immune, inhibitor, c3 convertase, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.700 Å )
Citation :

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.

Schubart, A.,Anderson, K.,Mainolfi, N.  et al.
(2019)  Proc.Natl.Acad.Sci.USA  116 : 7926 - 7931

PubMed: 30926668
DOI: 10.1073/pnas.1820892116

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.

Schubart, A.,Anderson, K.,Mainolfi, N.  et al.
(2019)  Proc.Natl.Acad.Sci.USA  116 : 7926 - 7931

PubMed: 30926668
DOI: 10.1073/pnas.1820892116

Reaction

Chain : AAA, BBB
UniProt : P00751 (CFAB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of Arg-|-Ser bond in complement component C3 alpha- chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b. 3.4.21.47 -
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