PDB ID: 6R8R
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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DMS | Dimethyl sulfoxide | PoSSuM | |||
EDO | 1,2-ethanediol | PoSSuM | |||
JV8 | ~{N}-isoquinolin-6-yl-2-(2-methylphenoxy)ethanamide | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
Code | Name | Show |
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Code | Name | Emphasize |
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NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose |
Code | Name | Show |
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Download interaction data: 6R8R
Structure summary
Code : | 6R8R PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | Structure of the Wnt deacylase Notum in complex with isoquinoline 45 | ||||||||||||
Release Data : | 2019-05-08 | ||||||||||||
Compound : |
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Source : |
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Authors : | Vecchia, L., Zhao, Y., Ruza, R.R., Jones, E.Y. | ||||||||||||
Keywords : | Wnt signalling, NOTUM Inhibitor, Crystallographic Fragment Screen, Hydrolase | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.2700 Å ) | ||||||||||||
Citation : |
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.
Atkinson, B.N.,Steadman, D.,Zhao, Y.
et al.
PubMed: 31534655 |
Reaction
Chain : | A | ||||||||
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UniProt : | Q6P988 (NOTUM_HUMAN) | ||||||||
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