Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
ADP Adenosine-5'-diphosphate
CL Chloride ion
GOL Glycerol
JRT 2-(benzimidazol-1-yl)-~{N}-(2-phenylethyl)ethanamide
MG Magnesium ion
Non-standard Residues
Code Name Show
TPO Phosphothreonine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 6R4A   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Aurora-A in complex with shape-diverse fragment 55
Release Data : 2019-05-08
Compound :
mol_id molecule chains synonym
1 Aurora kinase A A Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
Authors : Bayliss, R., McIntyre, P.J.
Keywords : Ser/Thr kinase Allosteric site, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.937 Å )
Citation :

Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.

Zhang, R.,McIntyre, P.J.,Collins, P.M.  et al.
(2019)  Chemistry  25 : 6831 - 6839

PubMed: 31026091
DOI: 10.1002/chem.201900815

Chain : A
UniProt : O14965 (AURKA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
-