Brand  (β version)

PDB ID: 6QXK

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Ligands
Code Name Style Show Link
JKW 2-[(1-methylpiperidin-4-yl)methylamino]-5-[[2-[4-(trifluoromethyloxy)phenyl]-1,3-thiazol-4-yl]methyl]-1,3-thiazol-4-one PoSSuM
Non-standard Residues
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Structure summary

Code : 6QXK   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human PIM1 bound to OX0999
Release Data : 2019-04-24
Compound :
mol_id molecule chains
1 Serine/threonine-protein kinase pim-1 B
ec: 2.7.11.1
mol_id molecule chains
2 Pimtide A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PIM1
expression_system_strain: BL21(DE3)
expression_system_plasmid: pLIC-SGC1
mol_id organism_scientific
2 Unidentified  (taxid:32630)
synthetic: yes
Authors : Alexander, L.T., Elkins, J.M., Russell, A., Bountra, C., Edwards, A.M., Knapp, S.
Keywords : Kinase, Structural Genomics Consortium, SGC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

PIM1 bound to OX0999

Knapp, S.,Elkins, J.M.,Alexander, L.T.  et al.
To Be Published 

Reaction

Chain : B
UniProt : P11309 (PIM1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:31548394
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:15525646, PubMed:15657054, PubMed:15808862
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