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Ligands
Code Name Style Show Link
A Adenosine-5'-monophosphate
FME N-formylmethionine
JJH Cadazolid
MG Magnesium ion
ZN Zinc ion
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 6QUL   PDBj   RCSB PDB   PDBe
Header : ANTIBIOTIC
Title : Structure of a bacterial 50S ribosomal subunit in complex with the novel quinoxolidinone antibiotic cadazolid
Release Data : 2019-04-10
Compound :
mol_id molecule chains
1 P-site fMet-tRNA(fMet) 1
mol_id molecule chains
2 23S rRNA A
mol_id molecule chains
3 5S rRNA B
mol_id molecule chains synonym
4 50S ribosomal protein L2 C ribosomal protein uL2
mol_id molecule chains synonym
5 50S ribosomal protein L3 D ribosomal protein uL3
mol_id molecule chains synonym
6 50S ribosomal protein L4 E ribosomal protein uL4
mol_id molecule chains synonym
7 50S ribosomal protein L5 F ribosomal protein uL5
mol_id molecule chains synonym
8 50S ribosomal protein L6 G ribosomal protein uL6
mol_id molecule chains synonym
9 50S ribosomal protein L9 H ribosomal protein bL9
mol_id molecule chains synonym
10 50S ribosomal protein L13 K ribosomal protein uL13
mol_id molecule chains synonym
11 50S ribosomal protein L14 L ribosomal protein uL14
mol_id molecule chains synonym
12 50S ribosomal protein L15 M ribosomal protein uL15
mol_id molecule chains synonym
13 50S ribosomal protein L16 N ribosomal protein uL16
mol_id molecule chains synonym
14 50S ribosomal protein L17 O ribosomal protein uL17
mol_id molecule chains synonym
15 50S ribosomal protein L18 P ribosomal protein uL18
mol_id molecule chains synonym
16 50S ribosomal protein L19 Q ribosomal protein bL19
mol_id molecule chains synonym
17 50S ribosomal protein L20 R ribosomal protein bL20
mol_id molecule chains synonym
18 50S ribosomal protein L21 S ribosomal protein bL21
mol_id molecule chains synonym
19 50S ribosomal protein L22 T ribosomal protein uL22
mol_id molecule chains synonym
20 50S ribosomal protein L23 U ribosomal protein uL23
mol_id molecule chains synonym
21 50S ribosomal protein L24 V ribosomal protein uL24
mol_id molecule chains synonym
22 50S ribosomal protein L25 W ribosomal protein bL25
mol_id molecule chains synonym
23 50S ribosomal protein L27 X ribosomal protein bL27
mol_id molecule chains synonym
24 50S ribosomal protein L28 Y ribosomal protein bL28
mol_id molecule chains synonym
25 50S ribosomal protein L29 Z ribosomal protein uL29
mol_id molecule chains synonym
26 50S ribosomal protein L30 a ribosomal protein uL30
mol_id molecule chains synonym
27 50S ribosomal protein L32 b ribosomal protein bL32
mol_id molecule chains synonym
28 50S ribosomal protein L33 c ribosomal protein bL33
mol_id molecule chains synonym
29 50S ribosomal protein L34 d ribosomal protein bL34
mol_id molecule chains synonym
30 50S ribosomal protein L35 e Ribosomal protein A,ribosomal protein bL35
mol_id molecule chains synonym
31 50S ribosomal protein L36 f Ribosomal protein B,ribosomal protein bL36
Source :
mol_id organism_scientific
1 Escherichia coli  (taxid:562)
mol_id organism_scientific
2 Escherichia coli  (taxid:562)
mol_id organism_scientific
3 Escherichia coli  (taxid:562)
mol_id organism_scientific
4 Escherichia coli  (taxid:562)
mol_id organism_scientific
5 Escherichia coli  (taxid:562)
mol_id organism_scientific
6 Escherichia coli  (taxid:562)
mol_id organism_scientific
7 Escherichia coli  (taxid:562)
mol_id organism_scientific
8 Escherichia coli  (taxid:562)
mol_id organism_scientific
9 Escherichia coli  (taxid:562)
mol_id organism_scientific
10 Escherichia coli  (taxid:562)
mol_id organism_scientific
11 Escherichia coli  (taxid:562)
mol_id organism_scientific
12 Escherichia coli  (taxid:562)
mol_id organism_scientific
13 Escherichia coli  (taxid:562)
mol_id organism_scientific
14 Escherichia coli  (taxid:562)
mol_id organism_scientific
15 Escherichia coli  (taxid:562)
mol_id organism_scientific
16 Escherichia coli  (taxid:562)
mol_id organism_scientific
17 Escherichia coli  (taxid:562)
mol_id organism_scientific
18 Escherichia coli  (taxid:562)
mol_id organism_scientific
19 Escherichia coli  (taxid:562)
mol_id organism_scientific
20 Escherichia coli  (taxid:562)
mol_id organism_scientific
21 Escherichia coli  (taxid:562)
mol_id organism_scientific
22 Escherichia coli  (taxid:562)
mol_id organism_scientific
23 Escherichia coli  (taxid:562)
mol_id organism_scientific
24 Escherichia coli  (taxid:562)
mol_id organism_scientific
25 Escherichia coli  (taxid:562)
mol_id organism_scientific
26 Escherichia coli  (taxid:562)
mol_id organism_scientific
27 Escherichia coli  (taxid:562)
mol_id organism_scientific
28 Escherichia coli  (taxid:562)
mol_id organism_scientific
29 Escherichia coli  (taxid:562)
mol_id organism_scientific
30 Escherichia coli  (taxid:562)
mol_id organism_scientific
31 Escherichia coli  (taxid:562)
Authors : Scaiola, A., Leibundgut, M., Boehringer, D., Ritz, D.
Keywords : ribosome, cadazolid, quinoxolidinone, 50S, ANTIBIOTIC
Exp. method : ELECTRON MICROSCOPY ( 3.0 Å )
Citation :

Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic.

Scaiola, A.,Leibundgut, M.,Boehringer, D.  et al.
(2019)  Sci Rep  9 : 5634 - 5634

PubMed: 30948752
DOI: 10.1038/s41598-019-42155-4

Chain : C
UniProt : P60422 (RL2_ECOLI)
Reaction : -
Chain : D
UniProt : P60438 (RL3_ECOLI)
Reaction : -
Chain : E
UniProt : P60723 (RL4_ECOLI)
Reaction : -
Chain : F
UniProt : P62399 (RL5_ECOLI)
Reaction : -
Chain : G
UniProt : P0AG55 (RL6_ECOLI)
Reaction : -
Chain : H
UniProt : P0A7R1 (RL9_ECOLI)
Reaction : -
Chain : K
UniProt : P0AA10 (RL13_ECOLI)
Reaction : -
Chain : L
UniProt : P0ADY3 (RL14_ECOLI)
Reaction : -
Chain : M
UniProt : P02413 (RL15_ECOLI)
Reaction : -
Chain : N
UniProt : P0ADY7 (RL16_ECOLI)
Reaction : -
Chain : O
UniProt : P0AG44 (RL17_ECOLI)
Reaction : -
Chain : P
UniProt : P0C018 (RL18_ECOLI)
Reaction : -
Chain : Q
UniProt : P0A7K6 (RL19_ECOLI)
Reaction : -
Chain : R
UniProt : P0A7L3 (RL20_ECOLI)
Reaction : -
Chain : S
UniProt : P0AG48 (RL21_ECOLI)
Reaction : -
Chain : T
UniProt : P61175 (RL22_ECOLI)
Reaction : -
Chain : U
UniProt : P0ADZ0 (RL23_ECOLI)
Reaction : -
Chain : V
UniProt : P60624 (RL24_ECOLI)
Reaction : -
Chain : W
UniProt : P68919 (RL25_ECOLI)
Reaction : -
Chain : X
UniProt : P0A7L8 (RL27_ECOLI)
Reaction : -
Chain : Y
UniProt : P0A7M2 (RL28_ECOLI)
Reaction : -
Chain : Z
UniProt : P0A7M6 (RL29_ECOLI)
Reaction : -
Chain : a
UniProt : P0AG51 (RL30_ECOLI)
Reaction : -
Chain : b
UniProt : P0A7N4 (RL32_ECOLI)
Reaction : -
Chain : c
UniProt : P0A7N9 (RL33_ECOLI)
Reaction : -
Chain : d
UniProt : P0A7P5 (RL34_ECOLI)
Reaction : -
Chain : e
UniProt : P0A7Q1 (RL35_ECOLI)
Reaction : -
Chain : f
UniProt : P0A7Q6 (RL36_ECOLI)
Reaction : -