Het-PDB Navi2 (PDB: 6QU7)

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Ligands
Code	Name	Link
ACT	Acetate ion	PoSSuM
FMN	Flavin mononucleotide	PoSSuM
JJE	~{N}-(2-chloranyl-6-fluoranyl-phenyl)-4-[4-ethyl-3-(hydroxymethyl)-5-oxidanylidene-1,2,4-triazol-1-yl]-5-fluoranyl-2-[(2~{S})-1,1,1-tris(fluoranyl)propan-2-yl]oxy-benzamide	PoSSuM
ORO	Orotic acid	PoSSuM
SO4	Sulfate ion	PoSSuM

Non-standard Residues
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Download interaction data: 6QU7

Code :

6QU7 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal structure of human DHODH in complex with BAY 2402234

Release Data :

2019-06-05

Compound :

mol_id	molecule	chains	synonym
1	Dihydroorotate dehydrogenase (quinone), mitochondrial	A	DHOdehase,Dihydroorotate oxidase
	ec: 1.3.5.2

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: DHODH

Authors :

Friberg, A., Gradl, S.

Keywords :

DHODH, OXIDOREDUCTASE

Exp. method :

X-RAY DIFFRACTION ( 1.52 Å )

Citation :

The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.

Christian, S.,Merz, C.,Evans, L. et al.
(2019) Leukemia 33 : 2403 - 2415

PubMed: 30940908
DOI: 10.1038/s41375-019-0461-5

PDB ID: 6QU7

Hetero Atom Contents

Structure summary

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