Brand  (β version)

PDB ID: 6QTN

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Ligands
Code Name Style Show Link
ACP Phosphomethylphosphonic acid adenylate ester PoSSuM
CA Calcium ion PoSSuM
EDO 1,2-ethanediol PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
GOL Glycerol PoSSuM
GTP Guanosine-5'-triphosphate PoSSuM
JHH Cyclostreptin PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6QTN   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE
Title : Tubulin-cyclostreptin complex
Release Data : 2019-04-03
Compound :
mol_id molecule chains synonym
1 Tubulin alpha-1B chain A,C Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
mol_id molecule chains
2 Tubulin beta-2B chain B,D
mol_id molecule chains synonym
3 Stathmin-4 E Stathmin-like protein B3,RB3
mol_id molecule chains
4 Tubulin-Tyrosine Ligase F
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
organ: Brain
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Cattle
organ: Brain
mol_id organism_scientific organism_common expression_system
3 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli  (taxid:562)
gene: Stmn4
mol_id organism_scientific organism_common expression_system
4 Gallus gallus  (taxid:9031) Chicken Escherichia coli  (taxid:562)
gene: TTL
Authors : Balaguer, F.d.A., Muehlethaler, T., Estevez-Gallego, J., Calvo, E., Gimenez-Abian, J.F., Risinger, A.L., Sorensen, E.J., Vanderwal, C.D., Altmann, K.-H., Mooberry, S.L., Steinmetz, M.O., Oliva, M.A., Prota, A.E., Diaz, J.F.
Keywords : CELL CYCLE, TUBULIN FOLD, CYTOSKELETON, MICROTUBULE
Exp. method : X-RAY DIFFRACTION ( 1.900 Å )
Citation :

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.

Balaguer, F.A.,Muhlethaler, T.,Estevez-Gallego, J.  et al.
(2019)  Int J Mol Sci  20

PubMed: 30897704
DOI: 10.3390/ijms20061392

Reaction

Chain : A, C
UniProt : P81947 (TBA1B_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate - UniProtKB:P68363
left-to-right
Chain : B, D
UniProt : Q6B856 (TBB2B_BOVIN)
Reaction : -
Chain : E
UniProt : P63043 (STMN4_RAT)
Reaction : -
Chain : F
UniProt : E1BQ43
Reaction : -