Het-PDB Navi2 (PDB: 6QOD)

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Ligands
Code	Name		Style	Show	Link
FBB	6-fluoro-1,3-benzothiazol-2-amine				PoSSuM

Non-standard Residues
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Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 6QOD

Code :

6QOD PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 7 (2-Amino-6-fluorobenzothiazole)

Release Data :

2020-03-04

Compound :

mol_id	molecule	chains	synonym
1	tRNA (guanine-N(1)-)-methyltransferase	A,B	M1G-methyltransferase,tRNA [GM37] methyltransferase
	ec: 2.1.1.228

Source :

mol_id	organism_scientific	expression_system
1	Mycobacterium abscessus (taxid:36809)	Escherichia coli (taxid:562)
	atcc: 19977 gene: trmD, MAB_3226c

Authors :

Thomas, S.E., Whitehouse, A.J., Coyne, A.G., Abell, C., Mendes, V., Blundell, T.L.

Keywords :

TrmD, tRNA methyltransferase, SPOUT methyltransferase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 1.8520 Å )

Citation :

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.

Thomas, S.E.,Whitehouse, A.J.,Brown, K. et al.
(2020) Nucleic Acids Res. 48 : 8099 - 8112

Chain :

A, B

UniProt :

B1MDI3 (B1MDI3_MYCA9)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)- methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine	2.1.1.228	ARBA:ARBA00001189, HAMAP- Rule:MF_00605, RuleBase:RU003464
	-	ARBA:ARBA00001189, HAMAP- Rule:MF_00605, RuleBase:RU003464

PDB ID: 6QOD