PDB ID: 6QMR
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Structure summary
Code : | 6QMR PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | Complement factor D in complex with the inhibitor (S)-2-(2-((3'-(1-amino-2-hydroxyethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)acetic acid | ||||||||||||
Release Data : | 2019-04-24 | ||||||||||||
Compound : |
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Source : |
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Authors : | Karki, R., Powers, J., Mainolfi, N., Anderson, K., Belanger, D., Liu, D., Jendza, K., Gelin, C.F., Solovay, C., Mac Sweeeny, A., Delgado, O., Crowley, M., Liao, S.-M., Argikar, U.A., Flohr, S., La Bonte, L.R., Lorthiois, E.L., Vulpetti, A., Cumin, F., Brown, A., Adams, C., Jaffee, B., Mogi, M. | ||||||||||||
Keywords : | Complement factor D, inhibitor, HYDROLASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.0000 Å ) | ||||||||||||
Citation : |
Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.
Karki, R.G.,Powers, J.,Mainolfi, N.
et al.
PubMed: 30995036 |
Reaction
Chain : | A, B, C, D, E, F | ||||||||
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UniProt : | P00746 (CFAD_HUMAN) | ||||||||
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