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Ligands
Code Name Style Show Link
NA Sodium ion
J08 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide
Non-standard Residues
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Glycosylation
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NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Code : 6QFE   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of Human Kallikrein 5 in complex with GSK144
Release Data : 2019-05-08
Compound :
mol_id molecule chains synonym
1 Kallikrein-5 A,B Kallikrein-like protein 2,KLK-L2,Stratum corneum tryptic enzyme
ec: 3.4.21.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Unidentified baculovirus  (taxid:10469)
gene: KLK5, SCTE, UNQ570/PRO1132
Authors : Thorpe, J.H.
Keywords : Protease, Inhibitor, Complex, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.6700 Å )
Citation :

Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.

Thorpe, J.H.,Edgar, E.V.,Smith, K.J.  et al.
(2019)  Acta Crystallogr.,Sect.F  75 : 385 - 391

PubMed: 31045568
DOI: 10.1107/S2053230X19003169

Chain : A, B
UniProt : Q9Y337 (KLK5_HUMAN)
Reaction : -