Brand  (β version)

PDB ID: 6Q8K

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
FG9 ~{N}2-(3-morpholin-4-ylpropyl)pyrido[3,4-G]quinazoline-2,10-diamine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6Q8K   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CLK1 with bound pyridoquinazoline
Release Data : 2019-02-20
Compound :
mol_id molecule chains synonym
1 Dual specificity protein kinase CLK1 A CDC-like kinase 1
ec: 2.7.12.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CLK1, CLK
Authors : Schroeder, M., Tazarki, H., Zeinyeh, W., Esvan, Y.J., Khiari, J., Joesselin, B., Bach, S., Ruchaud, S., Anizon, F., Giraud, F., Moreau, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Keywords : CLK1, Dual specifity protein kinase CLK1, Inhibitor, Kinase, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.29 Å )
Citation :

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis.

Tazarki, H.,Zeinyeh, W.,Esvan, Y.J.  et al.
(2019)  Eur J Med Chem  166 : 304 - 317

PubMed: 30731399
DOI: 10.1016/j.ejmech.2019.01.052

Reaction

Chain : A
UniProt : P49759 (CLK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.12.1 PubMed:10480872
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.12.1 UniProtKB:P22518
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ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.12.1 UniProtKB:P22518
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