PDB ID: 6PRF
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|Header :||Hydrolase/Hydrolase Inhibitor|
|Title :||HIV-1 Protease multiple drug resistant clinical isolate mutant PR20 with GRL-14213A|
|Release Data :||2019-09-18|
|Authors :||Kneller, D.W., Agniswamy, J., Weber, I.T.|
|Keywords :||Protease, Inhibitor, Multiple Mutant, Viral Protein complex, HYDROLASE, Hydrolase-Hydrolase Inhibitor, Hydrolase-Hydrolase Inhibitor complex|
|Exp. method :||X-RAY DIFFRACTION ( 1.2100 Å )|
|Chain :||A, B|
|UniProt :||P03366 (POL_HV1B1)|
|Reaction :||Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).