Het-PDB Navi2 (PDB: 6PAD)

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Ligands
Code	Name		Style	Show	Link
0PC	Nalpha-[(benzyloxy)carbonyl]-N-[(1s)-3-chloro-1-methyl-2-oxopropyl]-L-phenylalaninamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6PAD

Code :

6PAD PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Binding of chloromethyl ketone substrate analogues to crystalline papain

Release Data :

1977-04-12

Compound :

mol_id	molecule	chains
1	PAPAIN	A
	ec: 3.4.22.2

Source :

mol_id	organism_scientific	organism_common
1	Carica papaya (taxid:3649)	Papaya
	tissue: FRUIT LATEX

Authors :

Drenth, J., Kalk, K.H., Swen, H.M.

Keywords :

SULFHYDRYL PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.8 Å )

Citation :

Binding of chloromethyl ketone substrate analogues to crystalline papain.

Drenth, J.,Kalk, K.H.,Swen, H.M.
(1976) Biochemistry 15 : 3731 - 3738

PubMed: 952885
DOI: 10.1021/bi00662a014

The Structure of Papain

Drenth, J.,Jansonius, J.N.,Koekoek, R. et al.
(1971) Adv.Protein Chem. 25 : 79

The Structure of the Papain Molecule

Drenth, J.,Jansonius, J.N.,Koekoek, R. et al.
(1970) Philos.Trans.R.Soc.London,Ser.B 257 : 231

Structure of Papain

Drenth, J.,Jansonius, J.N.,Koekoek, R. et al.
(1968) Nature 218 : 929

(1976) Atlas of Macromolecular Structure on Microfiche : 276

(1972) Atlas of Protein Sequence and Structure (Data Section) 5 : 121

Chain :

UniProt :

P00784 (PAPA1_CARPA)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'.	3.4.22.2	PubMed:21416241, PubMed:23151624, PubMed:2404797
	-	PubMed:21416241, PubMed:23151624, PubMed:2404797

PDB ID: 6PAD

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