Brand  (β version)

PDB ID: 6NL5

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Ligands
Code Name Style Show Link
DCP 2'-deoxycytidine-5'-triphosphate PoSSuM
MG Magnesium ion PoSSuM
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Glycosylation
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Structure summary

Code : 6NL5   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with 2'-deoxycytidine triphosphate
Release Data : 2020-01-15
Compound :
mol_id molecule chains synonym
1 ATP-dependent dethiobiotin synthetase BioD A,B,C,D DTB synthetase,DTBS,Dethiobiotin synthase
ec: 6.3.3.3
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis H37Rv  (taxid:83332) Escherichia coli  (taxid:469008)
strain: ATCC 25618 / H37Rv
gene: bioD, Rv1570, MTCY336.33c
expression_system_strain: BL21 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET16b
Authors : Thompson, A.P., Polyak, S.W., Wegener, K.L., Bruning, J.B.
Keywords : enzyme, synthetase, nucleotide triphosphate binding, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.3140 Å )
Citation :

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with 2'-deoxycytidine triphosphate

Thompson, A.P.,Bruning, J.B.,Wegener, K.L.  et al.
To Be Published 

Reaction

Chain : A, B, C, D
UniProt : P9WPQ5 (BIOD_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)- dethiobiotin + ADP + 3 H(+) + phosphate 6.3.3.3 HAMAP- Rule:MF_00336
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