Brand  (β version)

PDB ID: 6N80

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Ligands
Code Name Style Show Link
JT7 N-[(1r)-1-borono-3-methylbutyl]-N~2~-(2-chloro-4-methoxybenzene-1-carbonyl)-L-leucinamide PoSSuM
Non-standard Residues
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Structure summary

Code : 6N80   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : S. aureus ClpP bound to anti-4a
Release Data : 2019-06-26
Compound :
mol_id molecule chains synonym
1 ATP-dependent Clp protease proteolytic subunit A,B,C,D,E,F,G,I,K,L,M,N,S,T Endopeptidase Clp
ec: 3.4.21.92
Source :
mol_id organism_scientific expression_system
1 Staphylococcus aureus (strain NCTC 8325)  (taxid:93061) Escherichia coli BL21(DE3)  (taxid:469008)
strain: NCTC 8325
gene: clpP, SAOUHSC_00790
Authors : Lee, R.E., Griffith, E.C.
Keywords : ClpP, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.96 Å )
Citation :

De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX.

Tan, J.,Grouleff, J.J.,Jitkova, Y.  et al.
(2019)  J.Med.Chem.  62 : 6377 - 6390

PubMed: 31187989
DOI: 10.1021/acs.jmedchem.9b00878

Reaction

Chain : A, B, C, D, E, F, G, I, K, L, M, N, S, T
UniProt : Q2G036 (CLPP_STAA8)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr- Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). 3.4.21.92 HAMAP-Rule:MF_00444
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