Brand  (β version)

PDB ID: 6MXO

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Ligands
Code Name Style Show Link
0KX 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine PoSSuM
9RD (cyclohex-1-ene-1,2-diamine)platinum(2+) PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6MXO   PDBj   RCSB PDB   PDBe
Header : NUCLEAR PROTEIN/DNA
Title : Structure of HPoleta incorporating dCTP opposite the 3-prime Pt(DACH)-GG
Release Data : 2019-02-13
Compound :
mol_id molecule chains synonym
1 DNA polymerase eta A RAD30 homolog A,Xeroderma pigmentosum variant type protein
ec: 2.7.7.7
mol_id molecule chains
2 DNA (5'-D(*AP*CP*GP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3') T
mol_id molecule chains
3 DNA (5'-D(*TP*AP*GP*TP*GP*TP*GP*AP*G)-3') P
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: POLH, RAD30, RAD30A, XPV
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
mol_id organism_scientific organism_common
3 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Ouzon-Shubeita, H., Lee, S.
Keywords : Y-family DNA polymerase, Pt(DACH)-GG, TRANSFERASE-DNA-INHIBITOR complex, NUCLEAR PROTEIN, NUCLEAR PROTEIN-DNA complex
Exp. method : X-RAY DIFFRACTION ( 2.04 Å )
Citation :

Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase eta.

Ouzon-Shubeita, H.,Baker, M.,Koag, M.C.  et al.
(2019)  Biochem. J.  476 : 747 - 758

PubMed: 30709915
DOI: 10.1042/BCJ20180848

Reaction

Chain : A
UniProt : Q9Y253 (POLH_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PubMed:27284197
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