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Ligands
Code Name Style Show Link
JYJ {4-[1-(3-chlorophenyl)cyclopropane-1-carbonyl]piperazin-1-yl}(thiophen-3-yl)methanone
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show
Code : 6MTN   PDBj   RCSB PDB   PDBe
Header : IMMUNE SYSTEM/INHIBITOR
Title : Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor Compound 484 in Complex with Human Antibodies 3H109L and 35O22 at 3.0 Angstrom
Release Data : 2019-01-16
Compound :
mol_id molecule chains synonym
1 Envelope glycoprotein gp160 B Env polyprotein
fragment: gp41
mutation: I559P, A605C
mol_id molecule chains
2 35O22 scFv heavy chain portion D
mutation: E10T, L11T, K12T, A16S, I68N, K83T, F84S,
mol_id molecule chains
3 35O22 scFv light chain portion E
mol_id molecule chains synonym
4 Envelope glycoprotein gp160 G Env polyprotein
fragment: gp120
mutation: N137A
mol_id molecule chains
5 3H109L Fab heavy chain H
mol_id molecule chains
6 3H109L Fab light chain L
mutation: E184M, S188M
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus 1  (taxid:11676) Homo sapiens  (taxid:9606)
gene: env
expression_system_common: Human
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
expression_system_common: Human
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
expression_system_common: Human
mol_id organism_scientific expression_system
4 Human immunodeficiency virus 1  (taxid:11676) Homo sapiens  (taxid:9606)
gene: env
mol_id organism_scientific organism_common expression_system
5 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
expression_system_common: Human
mol_id organism_scientific expression_system
6 Homo sapiens  (taxid:9606) Homo sapiens  (taxid:9606)
Authors : Lai, Y.-T., Kwong, P.D.
Keywords : HIV-1 Envelope Prefusion Trimer, Entry Inhibitors, IMMUNE SYSTEM-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.5000 Å )
Citation :

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.

Lai, Y.T.,Wang, T.,O'Dell, S.  et al.
(2019)  Nat Commun  10 : 47 - 47

PubMed: 30604750
DOI: 10.1038/s41467-018-07851-1

Chain : G
UniProt : Q2N0S6 (Q2N0S6_9HIV1)
Reaction : -