Brand  (β version)

PDB ID: 6MSN

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Ligands
Code Name Style Show Link
JYD (2s)-2-sulfanylbutanedioic acid PoSSuM
SF4 Iron/sulfur cluster PoSSuM
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Structure summary

Code : 6MSN   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of cytosolic fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate
Release Data : 2019-01-30
Compound :
mol_id molecule chains
1 fumarate hydratase A,B
ec: 4.2.1.2
Source :
mol_id organism_scientific expression_system
1 Leishmania major  (taxid:5664) Escherichia coli  (taxid:562)
gene: LMJF_29_1960
Authors : Feliciano, P.R., Drennan, C.L., Nonato, M.C.
Keywords : inhibitor, cytosolic, fumarate hydratase, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.591 Å )
Citation :

Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate.

Feliciano, P.R.,Drennan, C.L.,Nonato, M.C.
(2019)  ACS Chem. Biol.  14 : 266 - 275

PubMed: 30645090
DOI: 10.1021/acschembio.8b00972

Reaction

Chain : A, B
UniProt : E9AE57 (FUM2_LEIMA)
Reaction: EC: Evidence:
Physiological Direction:
(S)-malate = fumarate + H2O 4.2.1.2 PubMed:22569531, PubMed:27528683, PubMed:30645090
right-to-left PubMed:22569531
Cofactor: Evidence: Note:
[4Fe-4S] cluster ECO:0000269 | PubMed:27528683
Binds 1 [4Fe-4S] cluster per subunit.