Brand  (β version)

PDB ID: 6MOA

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
JW4 4-(2-cyclopropyl-7-(6-methylquinolin-5-yl)-1h-benzo[D]imidazol-5-yl)-3,5-dimethylisoxazole PoSSuM
Non-standard Residues
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Structure summary

Code : 6MOA   PDBj   RCSB PDB   PDBe
Header : transcription/transcription inhibitor
Title : C-terminal bromodomain of human BRD2 in complex with 4-(2-cyclopropyl-7-(6-methylquinolin-5-yl)-1H-benzo[D]imidazol-5-yl)-3,5-dimethylisoxazole inhibitor
Release Data : 2019-01-23
Compound :
mol_id molecule chains synonym
1 Bromodomain-containing protein 2 A O27.1.1,Really interesting new gene 3 protein
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BRD2, KIAA9001, RING3
Authors : Lansdon, E.B., Newby, Z.E.R.
Keywords : Inhibitor, epigenetic reader, bromodomain, transcription-transcription inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.271 Å )
Citation :

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

Sperandio, D.,Aktoudianakis, V.,Babaoglu, K.  et al.
(2019)  Bioorg. Med. Chem.  27 : 457 - 469

PubMed: 30606676
DOI: 10.1016/j.bmc.2018.11.020

Reaction

Chain : A
UniProt : P25440 (BRD2_HUMAN)
Reaction : -