Het-PDB Navi2 (PDB: 6MO7)

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Ligands
Code	Name		Style	Show	Link
JWA	N-({4-[3-(cyclopentylsulfamoyl)-4-methylphenyl]-3-methyl-1,2-oxazol-5-yl}methyl)acetamide				PoSSuM

Non-standard Residues
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Download interaction data: 6MO7

Code :

6MO7 PDBj RCSB PDB PDBe

Header :

transcription/transcription inhibitor

Title :

N-terminal bromodomain of human BRD2 with N-((4-(3-(N-cyclopentylsulfamoyl)-4-methylphenyl)-3-methylisoxazol-5-yl)methyl)acetamide inhibitor

Release Data :

2019-01-23

Compound :

mol_id	molecule	chains	synonym
1	Bromodomain-containing protein 2	A,B,C	O27.1.1,Really interesting new gene 3 protein

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: BRD2, KIAA9001, RING3

Authors :

Lansdon, E.B., Newby, Z.E.R.

Keywords :

Inhibitor, epigenetic reader, bromodomain, transcription-transcription inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.85 Å )

Citation :

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

Sperandio, D.,Aktoudianakis, V.,Babaoglu, K. et al.
(2019) Bioorg. Med. Chem. 27 : 457 - 469

PDB ID: 6MO7