Brand  (β version)

PDB ID: 6MNH

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
DMS Dimethyl sulfoxide PoSSuM
JVD N-[(2r)-3-methylbutan-2-yl]-1h-benzotriazole-6-carboxamide PoSSuM
Non-standard Residues
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CSO S-hydroxycysteine
SEP Phosphoserine
Glycosylation
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Structure summary

Code : 6MNH   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/INHIBITOR
Title : ULK1 Unc-51 like autophagy activating kinase in complex with inhibitor BTC
Release Data : 2019-03-27
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase ULK1 A Autophagy-related protein 1 homolog,hATG1,Unc-51-like kinase 1
ec: 2.7.11.1
mutation: S195A, S224A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ULK1, KIAA0722
Authors : Hendle, J., Sauder, J.M., Hickey, M.J., Rauch, C.T., Maletic, M., Schwinn, K.D.
Keywords : kinase, inhibitor, complex, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.73 Å )
Citation :

Idea2Data: Toward a New Paradigm for Drug Discovery.

Nicolaou, C.A.,Humblet, C.,Hu, H.  et al.
(2019)  Acs Med.Chem.Lett.  10 : 278 - 286

PubMed: 30891127
DOI: 10.1021/acsmedchemlett.8b00488

Reaction

Chain : A
UniProt : O75385 (ULK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:18936157, PubMed:25126726, PubMed:28821708, PubMed:31123703
left-to-right PubMed:18936157, PubMed:25126726, PubMed:31123703
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:18936157
left-to-right