Brand  (β version)

PDB ID: 6MNE

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
J3Z (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one PoSSuM
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
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Structure summary

Code : 6MNE   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRONE AND NADP+
Release Data : 2019-04-03
Compound :
mol_id molecule chains synonym
1 Estradiol 17-beta-dehydrogenase 1 A,B 17-beta-hydroxysteroid dehydrogenase type 1,17-beta-HSD 1,20 alpha-hydroxysteroid dehydrogenase,20-alpha-HSD,E2DH,Placental 17-beta-hydroxysteroid dehydrogenase,Short chain dehydrogenase/reductase family 28C member 1
ec: 1.1.1.62
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: HSD17B1, E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1
expression_system_strain: sf9
expression_system_plasmid: pFastBac
Authors : Li, T., Lin, S.X.
Keywords : 17BETA-HSD1, ESTRONE, FUNCTIONAL ANALYSES, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.8600 Å )
Citation :

Crystal structures of human 17 beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+reveal the mechanism of substrate inhibition.

Li, T.,Stephen, P.,Zhu, D.W.  et al.
(2019)  Febs J.  286 : 2155 - 2166

PubMed: 30768851
DOI: 10.1111/febs.14784

Reaction

Chain : A, B
UniProt : P14061 (DHB1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
17beta-estradiol + NAD(+) = estrone + H(+) + NADH 1.1.1.62 PubMed:8994190
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17beta-estradiol + NADP(+) = estrone + H(+) + NADPH 1.1.1.62 UniProtKB:P51656
right-to-left
NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH 1.1.1.51 UniProtKB:P51656
right-to-left