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Ligands
Code Name Style Show Link
JEY N-[2-(5-methoxy-2-phenyl-1h-indol-3-yl)ethyl]acetamide
OLC (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate
ZN Zinc ion
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Code : 6ME6   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : XFEL crystal structure of human melatonin receptor MT2 in complex with 2-phenylmelatonin
Release Data : 2019-04-24
Compound :
mol_id molecule chains synonym
1 Soluble cytochrome b562,Melatonin receptor type 1B,Rubredoxin A,B Cytochrome b-562,Mel1b receptor,Rd,Mel1b receptor
mutation: M2007W, H2102I, R2106L, P37S, D86N, L108F, F129W, N137D, C140L, W246F, A305P
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: MTNR1B
Authors : Johansson, L.C., Stauch, B., McCorvy, J., Han, G.W., Patel, N., Batyuk, A., Gati, C., Li, C., Grandner, J., Hao, S., Olsen, R.H.J., Tribo, A.R., Zaare, S., Zhu, L., Zatsepin, N.A., Weierstall, U., Liu, W., Roth, B.L., Katritch, V., Cherezov, V.
Keywords : GPCR, melatonin receptor type 1B (MT2), membrane protein, 2-phenylmelatonin, XFEL, LCP, BRIL, Rubredoxin, circadian rhythm, jetlag, type 2 diabetes
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity.

Johansson, L.C.,Stauch, B.,McCorvy, J.D.  et al.
(2019)  Nature  569 : 289 - 292

PubMed: 31019305
DOI: 10.1038/s41586-019-1144-0

Chain : A, B
UniProt : P0ABE7 (C562_ECOLX)
Reaction : -
Chain : A, B
UniProt : P49286 (MTR1B_HUMAN)
Reaction : -
Chain : A, B
UniProt : P00268 (RUBR_CLOPA)
Reaction : -