Het-PDB Navi2 (PDB: 6MDD)

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Ligands
Code	Name		Style	Show	Link
JE7	5-[(2,3-dichlorophenyl)sulfanyl]-3h-imidazo[4,5-B]pyridin-2-amine				PoSSuM
PO4	Phosphate ion				PoSSuM

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Download interaction data: 6MDD

Code :

6MDD PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Imidazo-pyridine 24

Release Data :

2019-02-13

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein phosphatase non-receptor type 11	A,B	Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3
	ec: 3.1.3.48

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PTPN11, PTP2C, SHPTP2

Authors :

Fodor, M., Stams, T.

Keywords :

SHP2, PTPN11, PROTEIN TYROSINE PHOSPHATASE, PHOSPHATASE, ALLOSTERIC INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.05 Å )

Citation :

Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.

Bagdanoff, J.T.,Chen, Z.,Acker, M. et al.
(2019) J. Med. Chem. 62 : 1781 - 1792

Chain :

A, B

UniProt :

Q06124 (PTN11_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate	3.1.3.48	PROSITE- ProRule:PRU10044, PubMed:20170098, PubMed:26742426, PubMed:28074573
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PDB ID: 6MDD