Het-PDB Navi2 (PDB: 6MAU)

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Ligands
Code	Name		Style	Show	Link
GOL	Glycerol				PoSSuM
JBS	1-(4-{6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[(3s)-3-phenylmorpholin-4-yl]quinazolin-2-yl}-1h-pyrazol-1-yl)-2-methylpropan-2-ol				PoSSuM

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Download interaction data: 6MAU

Code :

6MAU PDBj RCSB PDB PDBe

Header :

PROTEIN BINDING

Title :

Crystal structure of human BRD4(1) in complex with CN210 (compound 19)

Release Data :

2019-04-03

Compound :

mol_id	molecule	chains	synonym
1	Bromodomain-containing protein 4	A	Protein HUNK1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: BRD4, HUNK1 expression_system_vector_type: PLASMID expression_system_plasmid: PJEXPRESS401

Authors :

Nadupalli, A., Fontano, E., Connors, C.R., Chan, S.G., Olland, A.M., Lakshminarasimhan, D., White, A., Suto, R.K.

Keywords :

BRD4(1), protein binding

Exp. method :

X-RAY DIFFRACTION ( 2.1100 Å )

Citation :

Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases.

Yang, S.M.,Yoshioka, M.,Strovel, J.W. et al.
(2019) Bioorg. Med. Chem. Lett. 29 : 1220 - 1226

PDB ID: 6MAU