Het-PDB Navi2 (PDB: 6MAE)

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Ligands
Code	Name		Style	Show	Link
JBA	(2r)-3-{(5s)-3-[4-(cyclopropylethynyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)propanamide				PoSSuM
ZN	Zinc ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6MAE

Code :

6MAE PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

CHAIN A. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase PA-LPXC Complexed with (R)-3-((S)-3-(4-(cyclopropylethynyl)phenyl)-2-oxooxazolidin-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)propenamide

Release Data :

2019-01-23

Compound :

mol_id	molecule	chains	synonym
1	UDP-3-O-acyl-N-acetylglucosamine deacetylase	A	UDP-3-O-acyl-GlcNAc deacetylase,UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase
	ec: 3.5.1.108

Source :

mol_id	organism_scientific
1	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (taxid:208964)
	strain: ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1

Authors :

Shu, W.

Keywords :

LPXC, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.8000 Å )

Citation :

Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.

Lee, P.S.,Lapointe, G.,Madera, A.M. et al.
(2018) J. Med. Chem. 61 : 9360 - 9370

PubMed: 30226381
DOI: 10.1021/acs.jmedchem.8b01287

Chain :

UniProt :

P47205 (LPXC_PSEAE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate	3.5.1.108	HAMAP-Rule:MF_00388, PubMed:9068651
	-	HAMAP-Rule:MF_00388, PubMed:9068651
Cofactor:	Evidence:	Note:
Zn(2+)	ECO:0000255 \| HAMAP-Rule:MF_00388 ECO:0000269 \| PubMed:9068651	-

PDB ID: 6MAE

Hetero Atom Contents

Structure summary

Reaction