Brand  (β version)

PDB ID: 6M9R

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Ligands
Code Name Style Show Link
FE Fe (III) ion PoSSuM
J9Y (2s)-2-amino-5-{[(E)-amino(methylamino)methylidene](hydroxy)azaniumyl}pentanoate PoSSuM
Non-standard Residues
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Structure summary

Code : 6M9R   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of SznF from Streptomyces achromogenes var. streptozoticus NRRL 2697 with a bound N(delta)-hydroxy-N(omega)-methyl-L-arginine intermediate
Release Data : 2019-02-06
Compound :
mol_id molecule chains
1 SznF A,B
ec: 1.-.-.-
Source :
mol_id organism_scientific expression_system
1 Streptomyces achromogenes subsp. streptozoticus  (taxid:285532) Escherichia coli BL21(DE3)  (taxid:469008)
strain: NRRL 2697
gene: sznf
expression_system_vector_type: plasmid
expression_system_plasmid: pET-21b
Authors : Rohac, R., Mitchell, A.J., Boal, A.K.
Keywords : non-heme iron-dependent, cupin domain, helix bundle, monooxygenase, N-nitrosation, L-arginine derivative, metal-bound, ligand-bound, anaerobic, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.69 Å )
Citation :

An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin.

Ng, T.L.,Rohac, R.,Mitchell, A.J.  et al.
(2019)  Nature  566 : 94 - 99

PubMed: 30728519
DOI: 10.1038/s41586-019-0894-z