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Ligands
Code Name Style Show Link
J9G 3-benzyl-6-[(2,4-difluorophenyl)amino]-1,3-dihydro-2h-imidazo[4,5-B]pyridin-2-one
Non-standard Residues
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Glycosylation
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Code : 6M9L   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/INHIBITOR
Title : Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping - compound 10
Release Data : 2019-04-17
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a
ec: 2.7.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Unidentified baculovirus  (taxid:10469)
gene: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
Authors : Lane, W., Okada, K.
Keywords : SBDD, Structure Based Drug Design, P38, Kinase, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.45 Å )
Citation :

Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1.

Kaieda, A.,Takahashi, M.,Fukuda, H.  et al.
(2019)  Chemmedchem  14 : 1022 - 1030

PubMed: 30945818
DOI: 10.1002/cmdc.201900129

Chain : A
UniProt : Q16539 (MK14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right PubMed:11010976, PubMed:35857590