Brand  (β version)

PDB ID: 6M9H

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide PoSSuM
GOL Glycerol PoSSuM
J9D 4-({4-amino-6-[4-(2-hydroxyethyl)-1h-imidazol-1-yl]pyrimidin-2-yl}amino)benzonitrile PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6M9H   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : JAK2 JH2 in complex with diaminopyrimidine JAK040
Release Data : 2018-09-05
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase JAK2 A Janus kinase 2,JAK-2
ec: 2.7.10.2
mutation: W659A, W777A, F794H
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: JAK2
Authors : Puleo, D.E., Schlessinger, J., Jorgensen, W.L.
Keywords : TRANSFERASE/TRANSFERASE INHIBITOR, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.790 Å )
Citation :

JAK2 JH2 Binders

Puleo, D.E.,Schlessinger, J.
To Be Published 

Reaction

Chain : A
UniProt : O60674 (JAK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:15690087, PubMed:16174768, PubMed:7615558, PubMed:9618263
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000305
Mn(2+) was used in the in vitro kinase assay but Mg(2+) is likely to be the in vivo cofactor.