Brand  (β version)

PDB ID: 6M7X

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Ligands
Code Name Style Show Link
JD7 4-[(5s)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
Non-standard Residues
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Structure summary

Code : 6M7X   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of human CYP11B1 in complex with fadrozole
Release Data : 2018-11-21
Compound :
mol_id molecule chains synonym
1 Cytochrome P450 11B1, mitochondrial A,B CYPXIB1,Cytochrome P-450c11,Cytochrome P450C11,Steroid 11-beta-hydroxylase
ec: 1.14.15.4
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli DH5alpha  (taxid:668369)
gene: CYP11B1, S11BH
expression_system_strain: DH5alpha
expression_system_vector_type: Plasmid
expression_system_plasmid: pCWori+
Authors : Scott, E.E., Brixius-Anderko, S.
Keywords : Cytochrome P450, CYP11B1, S-fadrozole, cortisol, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.095 Å )
Citation :

Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design.

Brixius-Anderko, S.,Scott, E.E.
(2019)  J. Biol. Chem.  294 : 453 - 460

PubMed: 30425102
DOI: 10.1074/jbc.RA118.006214

Reaction

Chain : A, B
UniProt : P15538 (C11B1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a steroid + 2 reduced [adrenodoxin] + O2 + 2 H(+) = an 11beta- hydroxysteroid + 2 oxidized [adrenodoxin] + H2O 1.14.15.4 PubMed:12530636, PubMed:1518866, PubMed:1775135, PubMed:18215163, PubMed:23322723
left-to-right
11-deoxycortisol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = cortisol + 2 oxidized [adrenodoxin] + H2O - PubMed:12530636, PubMed:1775135, PubMed:18215163, PubMed:23322723
left-to-right
21-hydroxyprogesterone + 2 reduced [adrenodoxin] + O2 + 2 H(+) = corticosterone + 2 oxidized [adrenodoxin] + H2O - PubMed:12530636, PubMed:1518866, PubMed:1775135, PubMed:18215163, PubMed:23322723
left-to-right
Cofactor: Evidence: Note:
heme ECO:0000250 | UniProtKB:P19099
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