Brand  (β version)

PDB ID: 6M7I

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
J84 1-(2,4-dichlorophenyl)-4-(1h-tetrazol-5-yl)-1h-pyrazol-5-amine PoSSuM
Non-standard Residues
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Structure summary

Code : 6M7I   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/INHIBITOR
Title : Crystal structure of KPC-2 with compound 3
Release Data : 2019-04-17
Compound :
mol_id molecule chains synonym
1 Carbapenem-hydrolyzing beta-lactamase KPC A Carbapenem-hydrolyzing beta-lactamase KPC-1
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli BL21(DE3)  (taxid:469008)
gene: bla, kpc, kpc1
Authors : Akhtar, A., Chen, Y.
Keywords : Carbapenemase, tetrazole, inhibitor, complex, HYDROLASE, HYDROLASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.7010 Å )
Citation :

Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.

Torelli, N.J.,Akhtar, A.,DeFrees, K.  et al.
(2019)  Acs Infect Dis.  5 : 1013 - 1021

PubMed: 30942078
DOI: 10.1021/acsinfecdis.9b00052

Reaction

Chain : A
UniProt : Q9F663 (BLKPC_KLEPN)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PubMed:11257029, PubMed:33257320
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