Brand  (β version)

PDB ID: 6KG0

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Ligands
Code Name Style Show Link
C6P N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-cysteine PoSSuM
CL Chloride ion PoSSuM
IPA Isopropyl alcohol PoSSuM
Non-standard Residues
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Structure summary

Code : 6KG0   PDBj   RCSB PDB   PDBe
Header : BIOSYNTHETIC PROTEIN
Title : NifS from Helicobacter pylori, soaked with L-cysteine for 118 sec
Release Data : 2019-10-16
Compound :
mol_id molecule chains synonym
1 Cysteine desulfurase IscS A NifS
ec: 2.8.1.7
mutation: L2V, K138R
Source :
mol_id organism_scientific expression_system
1 Helicobacter pylori (strain ATCC 700392 / 26695)  (taxid:85962) Escherichia coli BL21(DE3)  (taxid:469008)
strain: ATCC 700392 / 26695
gene: iscS, HP_0220
expression_system_variant: C41
Authors : Nakamura, R., Takahashi, Y., Fujishiro, T.
Keywords : iron, sulfur, cysteine desulfurase, reaction intermediate, BIOSYNTHETIC PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.7800 Å )
Citation :

Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes.

Nakamura, R.,Hikita, M.,Ogawa, S.  et al.
(2020)  Febs J.  287 : 1138 - 1154

PubMed: 31587510
DOI: 10.1111/febs.15081

Reaction

Chain : A
UniProt : O25008 (ISCS_HELPY)
Reaction: EC: Evidence:
Physiological Direction:
(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L- alanine 2.8.1.7 HAMAP-Rule:MF_00331
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Cofactor: Evidence: Note:
pyridoxal 5'-phosphate ECO:0000255 | HAMAP-Rule:MF_00331
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