Brand  (β version)

PDB ID: 6K0T

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Ligands
Code Name Style Show Link
CTU 3-[(1~{E})-1-[8-[(8-chloranyl-2-cyclopropyl-imidazo[1,2-a]pyridin-3-yl)methyl]-3-fluoranyl-6~{H}-benzo[C][1]benzoxepin-11-ylidene]ethyl]-4~{H}-1,2,4-oxadiazol-5-one PoSSuM
Non-standard Residues
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CME S,S-(2-hydroxyethyl)thiocysteine
Glycosylation
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Structure summary

Code : 6K0T   PDBj   RCSB PDB   PDBe
Header : NUCLEAR PROTEIN
Title : Crystal Structure of PPARgamma Ligand Binding Domain in complex with dibenzooxepine derivative compound-17
Release Data : 2019-10-30
Compound :
mol_id molecule chains synonym
1 Peroxisome proliferator-activated receptor gamma A,C PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
mol_id molecule chains
2 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha B,D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PPARG, NR1C3
mol_id organism_scientific
2 Homo sapiens  (taxid:9606)
synthetic: yes
Authors : Suzuki, M., Yamamoto, K., Takahashi, Y., Saito, J.
Keywords : PPARgamma, Ligand binding domain, PPARg modulator, Cancer, NUCLEAR PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.84 Å )
Citation :

Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold.

Yamamoto, K.,Tamura, T.,Nakamura, R.  et al.
(2019)  Bioorg.Med.Chem.  27 : 115122 - 115122

PubMed: 31623970
DOI: 10.1016/j.bmc.2019.115122

Reaction

Chain : A, C
UniProt : P37231 (PPARG_HUMAN)
Reaction : -