Het-PDB Navi2 (PDB: 6JPJ)

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Ligands
Code	Name		Style	Show	Link
FGF	N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2h-1,8-naphthyridine-1-carboxamide				PoSSuM
SO4	Sulfate ion				PoSSuM

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Download interaction data: 6JPJ

Code :

6JPJ PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal structure of FGF401 in complex of FGFR4

Release Data :

2019-05-15

Compound :

mol_id	molecule	chains	synonym
1	Fibroblast growth factor receptor 4	A	FGFR-4
	ec: 2.7.10.1 mutation: C477A,R664E

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: FGFR4, JTK2, TKF

Authors :

Zhou, Z., Chen, X., Chen, Y.

Keywords :

FGF401, reversible covalent inhibitor, FGFR4, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.638 Å )

Citation :

Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4.

Zhou, Z.,Chen, X.,Fu, Y. et al.
(2019) Chem.Commun.(Camb.) 55 : 5890 - 5893

Chain :

UniProt :

P22455 (FGFR4_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:11433297, PubMed:17311277, PubMed:18480409, PubMed:18670643
	-

PDB ID: 6JPJ