Het-PDB Navi2 (PDB: 6J8I)

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Ligands
Code	Name		Style	Show	Link
9SR	(1r,5r,6r,7r,9s,11s,12s,13s,14s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name)				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 6J8I

Code :

6J8I PDBj RCSB PDB PDBe

Header :

MEMBRANE PROTEIN

Title :

Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (Y1755 up)

Release Data :

2019-02-27

Compound :

mol_id	molecule	chains
1	Sodium channel subunit beta-2	C

mol_id	molecule	chains	synonym
2	Sodium channel protein type 9 subunit alpha	A	Neuroendocrine sodium channel,hNE-Na,Peripheral sodium channel 1,PN1,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.7

mol_id	molecule	chains
3	Sodium channel subunit beta-1	B

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: SCN2B, UNQ326/PRO386 expression_system_common: Human

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: SCN9A, NENA expression_system_common: Human

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: SCN1B expression_system_common: Human

Authors :

Shen, H., Liu, D., Lei, J., Yan, N.

Keywords :

voltage-gated sodium channel, MEMBRANE PROTEIN

Exp. method :

ELECTRON MICROSCOPY ( 3.2 Å )

Citation :

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins.

Shen, H.,Liu, D.,Wu, K. et al.
(2019) Science 363 : 1303 - 1308

PubMed: 30765606
DOI: 10.1126/science.aaw2493

Chain :	C
UniProt :	O60939 (SCN2B_HUMAN)
Reaction :	-

Chain :

UniProt :

Q15858 (SCN9A_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Na(+)(in) = Na(+)(out)	-	PubMed:30661758, PubMed:7720699
Na(+)(in) = Na(+)(out)	-	PubMed:30661758, PubMed:7720699

Chain :	B
UniProt :	Q07699 (SCN1B_HUMAN)
Reaction :	-

PDB ID: 6J8I

Hetero Atom Contents

Structure summary

Reaction