Brand  (β version)

PDB ID: 6ISO

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
CRD (2e)-but-2-enal PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 6ISO   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Human SIRT3 Recognizing H3K4cr
Release Data : 2019-01-23
Compound :
mol_id molecule chains synonym
1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial A,B,E,G,I,K hSIRT3,Regulatory protein SIR2 homolog 3,SIR2-like protein 3
ec: 3.5.1.-
mol_id molecule chains
2 ARG-THR-LYS-GLN-THR-ALA-ARG C,D,F,H,L,J
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli-Pichia pastoris shuttle vector pPpARG4  (taxid:1182032)
gene: SIRT3, SIR2L3
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Wang, Y., Hao, Q.
Keywords : Posttranslational modification, Sirtuins, Histones, Complex., HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.95 Å )
Citation :

Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach.

Bao, X.,Wang, Y.,Li, X.  et al.
(2014)  Elife  3

PubMed: 25369635
DOI: 10.7554/eLife.02999

Reaction

Chain : A, B, E, G, I, K
UniProt : Q9NTG7 (SIR3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide 2.3.1.286 PROSITE-ProRule:PRU00236, PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:19535340, PubMed:24121500, PubMed:23283301
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