Brand  (β version)

PDB ID: 6I51

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Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide PoSSuM
F05 1h-isoindol-3-amine PoSSuM
NA Sodium ion PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
Code Name Show
TYS O-sulfo-L-tyrosine
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 6I51   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Thrombin in complex with fragment J02
Release Data : 2019-11-20
Compound :
mol_id molecule chains synonym
1 Prothrombin L Coagulation factor II
ec: 3.4.21.5
mol_id molecule chains synonym
2 Prothrombin H Coagulation factor II
ec: 3.4.21.5
mol_id molecule chains
3 Hirudin variant-2 I
other_details: HTTP://SHOP.BACHEM.COM/H-7425.HTML Contains Sulfated Tyrosine
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
tissue: Blood
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
tissue: Blood
mol_id organism_scientific organism_common
3 Hirudo medicinalis  (taxid:6421) Medicinal leech
synthetic: yes
Authors : Abazi, N., Heine, A., Klebe, G.
Keywords : COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, BLOOD CLOTTING INHIBITOR, THROMBIN INHIBITOR, PREORGANIZATION, GLYCOSYLATION, BLOOD, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.400 Å )
Citation :

Fragment screening of Thrombin using a 96 member fragment library

Abazi, N.,Heine, A.,Klebe, G.
To Be Published 

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : I
UniProt : P09945 (HIRV2_HIRME)
Reaction : -