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PDB ID: 6HNW

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Ligands
Code Name Style Show Link
CUE Coumestrol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 6HNW   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human protein kinase CK2 alpha in complex with coumestrol
Release Data : 2019-08-07
Compound :
mol_id molecule chains synonym
1 Casein kinase II subunit alpha A CK II alpha
ec: 2.7.11.1
fragment: kinase domain (residues 1-337)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSNK2A1, CK2A1
Authors : Battistutta, R., Lolli, G.
Keywords : kinase domain, transferase
Exp. method : X-RAY DIFFRACTION ( 2.0000 Å )
Citation :

Inhibitory Properties of ATP-Competitive Coumestrol and Boldine Are Correlated to Different Modulations of CK2 Flexibility.

Battistutta, R.,Lolli, G.
(2019)  J.Nat.Prod.  82 : 1014 - 1018

PubMed: 30840451
DOI: 10.1021/acs.jnatprod.8b00889

Reaction

Chain : A
UniProt : P68400 (CSK21_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:20545769, PubMed:20625391, PubMed:21482717, PubMed:22184066, PubMed:23123191, PubMed:30699359, PubMed:30898438, PubMed:31439799
left-to-right PubMed:20545769, PubMed:21482717, PubMed:23123191, PubMed:30699359, PubMed:30898438, PubMed:31439799, PubMed:35597237
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:20625391, PubMed:22325354, PubMed:31439799
left-to-right PubMed:31439799