Brand  (β version)

PDB ID: 6HH4

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
F2R Adp-ribosyl-L-arginine PoSSuM
GOL Glycerol PoSSuM
ACT Acetate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6HH4   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with ADP-ribosyl-L-arginine
Release Data : 2018-11-28
Compound :
mol_id molecule chains
1 ADP-ribosylhydrolase like 2 A,B
Source :
mol_id organism_scientific organism_common expression_system
1 Latimeria chalumnae  (taxid:7897) West Indian ocean coelacanth Escherichia coli  (taxid:562)
gene: ADPRHL2
Authors : Ariza, A.
Keywords : ADP-ribosylation, ADP-ribose, ADPRHL2, ADP-ribosylhydrolase like 2, HYDROLASE, Arg-ADPr, Argenine-ADPr, ADP-Ribosyl-L-arginine
Exp. method : X-RAY DIFFRACTION ( 1.66 Å )
Citation :

(ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition.

Rack, J.G.M.,Ariza, A.,Drown, B.S.  et al.
(2018)  Cell Chem Biol  25 : 1533 - 1546.e12

PubMed: 30472116
DOI: 10.1016/j.chembiol.2018.11.001

Reaction

Chain : A, B
UniProt : H3BCW1 (ADPRS_LATCH)
Reaction: EC: Evidence:
Physiological Direction:
[(1''->2')-ADP-alpha-D-ribose](n) + H2O = [(1''->2')-ADP- alpha-D-ribose](n-1) + ADP-D-ribose 3.2.1.143 PubMed:30472116
left-to-right
1''-O-acetyl-ADP-alpha-D-ribose + H2O = acetate + ADP-D-ribose + H(+) - UniProtKB:Q9NX46
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H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] = ADP-D-ribose + L- seryl-[protein] - PubMed:30472116
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alpha-NAD(+) + H2O = ADP-D-ribose + H(+) + nicotinamide - UniProtKB:Q9NX46
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