Brand  (β version)

PDB ID: 6HEZ

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Ligands
Code Name Style Show Link
0SK 8-(hydroxyamino)-2-[(2s)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-6-(trifluoromethyl)-4h-1,3-benzothiazin-4-one PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
IMD Imidazole PoSSuM
Non-standard Residues
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Structure summary

Code : 6HEZ   PDBj   RCSB PDB   PDBe
Header : FLAVOPROTEIN
Title : M tuberculosis DprE1 in complex with BTZ043
Release Data : 2018-08-29
Compound :
mol_id molecule chains synonym
1 Decaprenylphosphoryl-beta-D-ribose oxidase A,B Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase,Decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase subunit DprE1,Decaprenyl-phosphoribose 2'-epimerase subunit 1,Decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase,Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit,FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase
ec: 1.1.98.3
other_details: Covalent ligand BTZ043 is bound to Cys387 (residue 408) in the alignment and has been modelled as non-standard amino acid Z43
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli BL21(DE3)  (taxid:469008)
gene: dprE1, Rv3790
Authors : Futterer, K., Batt, S.M., Besra, G.S.
Keywords : oxidation-reduction process, isomerase, arabinan biosynthetic process, FLAVOPROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.

Richter, A.,Rudolph, I.,Mollmann, U.  et al.
(2018)  Sci Rep  8 : 13473 - 13473

PubMed: 30194385
DOI: 10.1038/s41598-018-31316-6

Reaction

Chain : A, B
UniProt : P9WJF1 (DPRE1_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D- ribofuranose = FADH2 + trans,octa-cis-decaprenylphospho-beta-D- erythro-pentofuranosid-2-ulose 1.1.98.3 PubMed:22733761
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