Brand  (β version)

PDB ID: 6HDR

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Ligands
Code Name Style Show Link
CC9 Curcumin PoSSuM
DTD Dithiane diol PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
Code Name Show
PTR O-phosphotyrosine
SEP Phosphoserine
Glycosylation
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Structure summary

Code : 6HDR   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human DYRK2 bound to Curcumin
Release Data : 2019-08-28
Compound :
mol_id molecule chains
1 Dual specificity tyrosine-phosphorylation-regulated kinase 2 A
ec: 2.7.12.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DYRK2
expression_system_cell_line: BL21(DE3)
Authors : Elkins, J.M., Soundararajan, M., Vollmar, M., Krojer, T., Bountra, C., Edwards, A.M., Arrowsmith, C., Knapp, S.
Keywords : Kinase, Structural Genomics Consortium, SGC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

DYRK2 bound to Curcumin

Elkins, J.M.,Knapp, S.
To Be Published 

Reaction

Chain : A
UniProt : Q92630 (DYRK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.12.1 PubMed:22998443
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.12.1 PubMed:22998443
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ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.12.1 PubMed:22998443
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