Brand  (β version)

PDB ID: 6HDQ

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
FZE 8-(((1r,2r,3r,5s)-2-(2-(4,4-difluorocyclohexyl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1h)-one PoSSuM
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Structure summary

Code : 6HDQ   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH : 8-(((1R,2R,3R,5S)-2-(2-(4,4-difluorocyclohexyl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one
Release Data : 2018-09-26
Compound :
mol_id molecule chains synonym
1 Bromodomain-containing protein 4 A Protein HUNK1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BRD4, HUNK1
Authors : Chung, C.
Keywords : INHIBITOR, HISTONE, EPIGENETIC READER, BROMODOMAIN, BRD4, BROMODOMAIN CONTAINING PROTEIN 4, ANTAGONIST, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors.

Bamborough, P.,Chung, C.W.,Furze, R.C.  et al.
(2018)  J. Med. Chem.  61 : 8321 - 8336

PubMed: 30226378
DOI: 10.1021/acs.jmedchem.8b00862

Reaction

Chain : A
UniProt : O60885 (BRD4_HUMAN)
Reaction : -