Brand  (β version)

PDB ID: 6HDO

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
FZH 8-[[(1~{S},2~{R},3~{R},5~{R})-2-[2-[1,1-bis(oxidanylidene)thian-4-yl]ethyl]-8-azabicyclo[3.2.1]octan-3-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1~{H}-quinolin-2-one PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6HDO   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of human ATAD2 bromodomain in complex with 8-(((1R,2R,3R,5S)-2-(2-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)quinolin-2(1H)-one
Release Data : 2018-09-26
Compound :
mol_id molecule chains synonym
1 ATPase family AAA domain-containing protein 2 A AAA nuclear coregulator cancer-associated protein,ANCCA
ec: 3.6.1.3
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ATAD2, L16, PRO2000
expression_system_plasmid: pNIC28-Bsa4
Authors : Chung, C.
Keywords : INHIBITOR, ATAD2, BROMODOMAIN, EPIGENETICS, ATPase family AAA domain-containing protein 2, transcription
Exp. method : X-RAY DIFFRACTION ( 2.61 Å )
Citation :

Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors.

Bamborough, P.,Chung, C.W.,Furze, R.C.  et al.
(2018)  J. Med. Chem.  61 : 8321 - 8336

PubMed: 30226378
DOI: 10.1021/acs.jmedchem.8b00862

Reaction

Chain : A
UniProt : Q6PL18 (ATAD2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O = ADP + H(+) + phosphate - -
-