Het-PDB Navi2 (PDB: 6HDN)

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Ligands
Code	Name	Link
EDO	1,2-ethanediol	PoSSuM
FZB	3-methyl-8-((8-methyl-8-azabicyclooctan-3-yl)amino)-1,7-naphthyridin-2(1h)-one	PoSSuM
SO4	Sulfate ion	PoSSuM

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Download interaction data: 6HDN

Code :

6HDN PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Crystal structure of human ATAD2 bromodomain in complex with 3-methyl-8-((8-methyl-8-azabicyclooctan-3-yl)amino)-1,7-naphthyridin-2(1H)-one

Release Data :

2018-09-26

Compound :

mol_id	molecule	chains	synonym
1	ATPase family AAA domain-containing protein 2	A	AAA nuclear coregulator cancer-associated protein,ANCCA
	ec: 3.6.1.3 other_details: SM remains from tag cleavage

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: ATAD2, L16, PRO2000 expression_system_plasmid: pNIC28-Bsa4

Authors :

Chung, C.

Keywords :

INHIBITOR, ATAD2, BROMODOMAIN, EPIGENETICS, ATPase family AAA domain-containing protein 2, transcription

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors.

Bamborough, P.,Chung, C.W.,Furze, R.C. et al.
(2018) J. Med. Chem. 61 : 8321 - 8336

Chain :

UniProt :

Q6PL18 (ATAD2_HUMAN)

PDB ID: 6HDN