Brand  (β version)

PDB ID: 6HCV

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FYE 6-fluoranyl-~{N}-[(1-oxidanylcyclohexyl)methyl]-4-oxidanylidene-chromene-2-carboxamide PoSSuM

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Structure summary

Code : 6HCV   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with a chromone ligand
Release Data : 2019-04-03
Compound :
mol_id molecule chains synonym
1 Lysine--tRNA ligase A,B Lysyl-tRNA synthetase
ec: 6.1.1.6
Source :
mol_id organism_scientific expression_system
1 Plasmodium falciparum 3D7  (taxid:36329) Escherichia coli  (taxid:562)
gene: PF3D7_1350100
Authors : Robinson, D.A., Baragana, B., Norcross, N., Forte, B., Walpole, C., Gilbert, I.H.
Keywords : ADENYLYLTRANSFERASE ACTIVITY, TRNA BINDING, LIGASE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.2000 Å )
Citation :

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Baragana, B.,Forte, B.,Choi, R.  et al.
(2019)  Proc.Natl.Acad.Sci.USA  116 : 7015 - 7020

PubMed: 30894487
DOI: 10.1073/pnas.1814685116

Reaction

Chain : A, B
UniProt : Q8IDJ8 (Q8IDJ8_PLAF7)
Reaction: EC: Evidence:
Physiological Direction:
tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate 6.1.1.6 ARBA:ARBA00048573, RuleBase:RU003748
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