Brand  (β version)

PDB ID: 6HBN

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
FXB 5-propan-2-yl-4-prop-2-enoxy-7,8-dihydro-6~{H}-indeno[1,2-B]indole-9,10-dione PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6HBN   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : HIGH-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA/CSKN2A1 GENE PRODUCT) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR THN27
Release Data : 2019-03-27
Compound :
mol_id molecule chains synonym
1 Casein kinase II subunit alpha A,B CK II alpha
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSNK2A1, CK2A1
Authors : Niefind, K., Hochscherf, J., Dimper, V., Witulski, B., Lindenblatt, D., Jose, J., Le Borgne, M.
Keywords : protein kinase CK2, casein kinase 2, catalytic subunit CK2alpha, CSNK2A1, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.590 Å )
Citation :

Diacritic Binding of an Indenoindole Inhibitor by CK2 alpha Paralogs Explored by a Reliable Path to Atomic Resolution CK2 alpha ' Structures.

Lindenblatt, D.,Nickelsen, A.,Applegate, V.M.  et al.
(2019)  Acs Omega  4 : 5471 - 5478

PubMed: 31559376
DOI: 10.1021/acsomega.8b03415

Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2alpha and Its Paralog CK2alpha'

Hochscherf, J.,Lindenblatt, D.,Witulski, B.  et al.
(2017)  Pharmaceuticals (Basel)  10

PubMed: 29236079
DOI: 10.3390/ph10040098

Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.

Ermakova, I.,Boldyreff, B.,Issinger, O.G.  et al.
(2003)  J. Mol. Biol.  330 : 925 - 934

PubMed: 12860116

Reaction

Chain : A, B
UniProt : P68400 (CSK21_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:20545769, PubMed:20625391, PubMed:21482717, PubMed:22184066, PubMed:23123191, PubMed:30699359, PubMed:30898438, PubMed:31439799
left-to-right PubMed:20545769, PubMed:21482717, PubMed:23123191, PubMed:30699359, PubMed:30898438, PubMed:31439799, PubMed:35597237
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:20625391, PubMed:22325354, PubMed:31439799
left-to-right PubMed:31439799