Het-PDB Navi2 (PDB: 6HAZ)

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Ligands
Code	Name		Style	Show	Link
FX5	2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol				PoSSuM
ZN	Zinc ion				PoSSuM

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Download interaction data: 6HAZ

Code :

6HAZ PDBj RCSB PDB PDBe

Header :

GENE REGULATION

Title :

Crystal structure of the bromodomain of human SMARCA2 in complex with SMARCA-BD ligand

Release Data :

2019-06-12

Compound :

mol_id	molecule	chains	synonym
1	Probable global transcription activator SNF2L2	A,B	ATP-dependent helicase SMARCA2,BRG1-associated factor 190B,BAF190B,Protein brahma homolog,hBRM,SNF2-alpha,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
	ec: 3.6.4.-

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: SMARCA2, BAF190B, BRM, SNF2A, SNF2L2 expression_system_vector_type: plasmid expression_system_plasmid: pDEST15

Authors :

Bader, G., Steurer, S., Weiss-Puxbaum, A., Zoephel, A., Roy, M., Ciulli, A.

Keywords :

bromodomain, GENE REGULATION

Exp. method :

X-RAY DIFFRACTION ( 1.3100 Å )

Citation :

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.

Farnaby, W.,Koegl, M.,Roy, M.J. et al.
(2019) Nat.Chem.Biol. 15 : 672 - 680

Chain :

A, B

UniProt :

P51531 (SMCA2_HUMAN)

PDB ID: 6HAZ