Brand  (β version)

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hetatm:

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information
centroid:
interaction residue:

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Ligands
Code Name Link
FX5 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol
ZN Zinc ion
Code : 6HAZ
Header : GENE REGULATION
Title : Crystal structure of the bromodomain of human SMARCA2 in complex with SMARCA-BD ligand
Release Data : 2019-06-12
Compound :
mol_id molecule chains synonym
1 Probable global transcription activator SNF2L2 A,B ATP-dependent helicase SMARCA2,BRG1-associated factor 190B,BAF190B,Protein brahma homolog,hBRM,SNF2-alpha,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
ec: 3.6.4.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: SMARCA2, BAF190B, BRM, SNF2A, SNF2L2
expression_system_vector_type: plasmid
expression_system_plasmid: pDEST15
Authors : Bader, G., Steurer, S., Weiss-Puxbaum, A., Zoephel, A., Roy, M., Ciulli, A.
Keywords : bromodomain, GENE REGULATION
Exp. method : X-RAY DIFFRACTION ( 1.3100 Å )
Citation :

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.

Farnaby, W.,Koegl, M.,Roy, M.J.  et al.
(2019)  Nat.Chem.Biol.  15 : 672 - 680

PubMed: 31178587
DOI: 10.1038/s41589-019-0294-6

Chain : A, B
UniProt : P51531 (SMCA2_HUMAN)
Reaction : -