Brand  (β version)

PDB ID: 6H9E

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Ligands
Code Name Style Show Link
B12 Cobalamin PoSSuM
FWK (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-ethyl-oxolane-3,4-diol PoSSuM
GOL Glycerol PoSSuM
TAR D(-)-tartaric acid PoSSuM
Non-standard Residues
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Structure summary

Code : 6H9E   PDBj   RCSB PDB   PDBe
Header : ISOMERASE
Title : Structure of glutamate mutase reconstituted with homo-coenzyme B12
Release Data : 2019-08-14
Compound :
mol_id molecule chains synonym
1 Glutamate mutase sigma subunit A,C Glutamate mutase S chain,Glutamate mutase small subunit,Methylaspartate mutase
ec: 5.4.99.1
other_details: small subunit
mol_id molecule chains synonym
2 Glutamate mutase epsilon subunit B,D Glutamate mutase E chain,Glutamate mutase large subunit,Methylaspartate mutase
ec: 5.4.99.1
other_details: large subunit
Source :
mol_id organism_scientific expression_system
1 Clostridium cochlearium  (taxid:1494) Escherichia coli  (taxid:562)
gene: glmS
mol_id organism_scientific expression_system
2 Clostridium cochlearium  (taxid:1494) Escherichia coli  (taxid:562)
gene: glmE
Authors : Gruber, K., Csitkovits, V., Kratky, C.
Keywords : COENZYME B12, CO-C-BOND, RADICAL REACTION, TIM-BARREL, ROSSMAN-FOLD, ISOMERASE
Exp. method : X-RAY DIFFRACTION ( 1.82 Å )
Citation :

Structure-Based Demystification of Radical Catalysis by a Coenzyme B 12 Dependent Enzyme-Crystallographic Study of Glutamate Mutase with Cofactor Homologues.

Gruber, K.,Csitkovits, V.,Lyskowski, A.  et al.
(2022)  Angew.Chem.Int.Ed.Engl.  61 : e202208295 - e202208295

PubMed: 35793207
DOI: 10.1002/anie.202208295

Reaction

Chain : A, C
UniProt : P80078 (GMSS_CLOCO)
Reaction: EC: Evidence:
Physiological Direction:
(2S,3S)-3-methyl-L-aspartate = L-glutamate 5.4.99.1 HAMAP-Rule:MF_00526, PubMed:7880251, PubMed:8013871
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Chain : B, D
UniProt : P80077 (GLME_CLOCO)
Reaction: EC: Evidence:
Physiological Direction:
(2S,3S)-3-methyl-L-aspartate = L-glutamate 5.4.99.1 HAMAP-Rule:MF_01923, PubMed:1315276, PubMed:7880251
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