Brand  (β version)

PDB ID: 6H9B

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Ligands
Code Name Style Show Link
FWH 9-methyl-3-[1-(2-methylquinolin-4-yl)ethenyl]carbazole PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
GTP Guanosine-5'-triphosphate PoSSuM
MG Magnesium ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6H9B   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN
Title : 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation
Release Data : 2018-12-19
Compound :
mol_id molecule chains
1 Tubulin alpha chain A,C
mol_id molecule chains
2 Tubulin beta chain B,D
mol_id molecule chains synonym
3 Stathmin-4 E Stathmin-like protein B3,RB3
mutation: C14A, F20W
Source :
mol_id organism_scientific
1 Ovis aries  (taxid:9940)
mol_id organism_scientific
2 Ovis aries  (taxid:9940)
mol_id organism_scientific organism_common expression_system
3 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Stmn4
Authors : Varela, P.F., Gigant, B.
Keywords : cytoskeleton, cell division, intracellular transport, TRANSPORT PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.75 Å )
Citation :

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.

Naret, T.,Khelifi, I.,Provot, O.  et al.
(2019)  J. Med. Chem.  62 : 1902 - 1916

PubMed: 30525602
DOI: 10.1021/acs.jmedchem.8b01386

Reaction

Chain : E
UniProt : P63043 (STMN4_RAT)
Reaction : -