Het-PDB Navi2 (PDB: 6H8S)

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Ligands
Code	Name		Style	Show	Link
FSZ	1-[3-piperidin-4-yl-5-(trifluoromethyl)phenyl]guanidine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6H8S

Code :

6H8S PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

CRYSTAL STRUCTURE OF THE MOUSE PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP) IN COMPLEX WITH COMPOUND BI-0314

Release Data :

2018-09-26

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein phosphatase non-receptor type 5	A	Neural-specific protein-tyrosine phosphatase,Striatum-enriched protein-tyrosine phosphatase,STEP
	ec: 3.1.3.48

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Escherichia coli (taxid:562)
	gene: Ptpn5

Authors :

Fiegen, D., Schnapp, G.

Keywords :

PROTEIN PHOSPHATASE, PTN5, STEP, ALLOSTERIC MODULATOR, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.771 Å )

Citation :

Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule.

Tautermann, C.S.,Binder, F.,Buttner, F.H. et al.
(2019) J. Med. Chem. 62 : 306 - 316

Chain :

UniProt :

P54830 (PTN5_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate	3.1.3.48	PROSITE- ProRule:PRU10044
	-	PROSITE- ProRule:PRU10044

PDB ID: 6H8S